Protein structure and dynamics

Description of projects available to graduate students:
All projects are related to the molecular analysis of the relationship between sequence, structure, dynamics, interactions and function of proteins. The focus of the lab is in the study of the mechanisms of folding and signal transduction by membrane receptors.

Techniques graduate student will learn:
Depending on which aspect of a project or which particular techniques a student is interested in, we can carve out a specific project within the
overall goals described above. The project can involve one or more of the following techniques: site-directed mutagenesis, expression of proteins in prokaryotic and/or mammalian expression systems, purification of proteins from natural and recombinant sources, refolding of proteins, biochemical characterization of proteins, biophysical characterization of (folded and unfolded) proteins (absorbance, fluorescence, NMR spectroscopy), statistical analysis of protein sequences, structure prediction, protein or ligand docking, systems biology.