Signal transduction in immunity, oncogenesis and viral pathogenesis

Description of projects available to graduate students:
We will use two different but complementary model systems to investigate the role of various signaling pathways, particularly the NF-kappaB and autophagy pathways and their cross-talk, in tumorigenesis: one model will involves tumors associated with chronic inflammation, the other one will utilize adult T-cell leukemia/lymphoma driven by retrovirus HTLV and its encoded Tax oncogene.

Techniques graduate student will learn:
Cell transfection and infection, ChIP, Chromatography, Confocal immunofluorescence, DNA Subcloning, ELISA, EMSA, FACS, IB, IP-IB, Immunohistochemistry, Mouse bone marrow transplantation, Mouse intraperitoneal injection, Mouse subcutaneous injection, Northern blot, Southern blot, Transgenic mouse generation, Knockout mouse generation, PCR, QPCR, etc.