Safe Gene Therapy for Type 1 DiabetesDate Added: 5/19/2011 1:55:00 PM
Last Updated: 5/24/2011 3:18:00 PM
Description of projects available to graduate students:
The aim is to create a window of opportunity in which a considerable chimerism -- between the resistance Asp57+ DQ beta chain-transfected versus original, non-transfected hematopoietic cells, expressing a susceptibility non-Asp57+ DQ beta chain -- will be present in the patient thymus long enough to centrally delete new, autoreactive T-cell clones, while promoting regulatory T-cell expansion.
Techniques graduate student will learn:
Generate knockout mice to study the expression of single gene encoding diabetes autoantigens in the medulla cells of the thymus.
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