c-Met signaling in lung cancerDate Added: 5/20/2011 9:53:00 AM
Last Updated: 5/24/2011 3:18:00 PM
Description of projects available to graduate students:
Our laboratory studies hormones and growth factors that control lung cancer growth and survival. This project will examine the hepatocyte growth factor (HGF) and its receptor, c-Met. Downstream effects of c-Met signaling will be measured, including how this receptor tyrosine kinase cross-activates other receptors such as the epidermal growth factor receptor. Use of selective inihibitors of HGF and c-Met to reduce lung cancer growth and survival, alone and in combination with other targeted anti-cancer drugs, will be pursued.
Techniques graduate student will learn:
immunoblotting, cell culture, ELISA assays, siRNA, animal xenografts, confocal and immunofluorescent microscopy, immunoprecipitation, MTA assay, immunohistochemistry
Cellular And Molecular Pathology
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