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Research
Interests |
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- Th1/Th2 differentiation and crossregulation and mathematical modeling of those interactions. This project involves the use of TCR transgenic mice and the tracking of immune responses in vivo.
- Role of dendritic cells in therapy of autoimmune diabetes using a murine diabetes model, the NOD mouse. We have identified dendritic cell subsets that protect NOD mice from diabetes development. Current studies are focused on the mechanism of action of the induced protection
- Fc receptor function on human NK cells. In this study the function of normal NK cells from individuals with defined allelic polymorphisms is analyzed. A more recently funded project is concerned with the assessment of FcR allelic polymorphisms as risk factors of disease severity for patients with rheumatoid arthritis.
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Selected
Publications |
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- Stewart-Akers AM, Cunningham A, Wasko MC, Morel PA. FcγR expression on NK cells influences disease severity in rheumatoid arthritis. Genes Immunity 5:521-529. 2004.
- Chen X-P, Falkner DH, Morel PA. Intrinsic Defect in IL-4 Impaired IL-4 production by CD8+ T cells in NOD mice is related to a defect of c-Maf binding to the IL-4 promoter. Eur J Immunol 35:1408-1417. 2005.
- Feili-Hariri M, Falkner DH, Morel PA. Polarization of naive T cells into Th1 or Th2 by distinct cytokine-driven dendritic cell populations: Implications for immunotherapy. J Leuk Biol 78:656-664. 2005.
- Ahrens ET, Flores R, Xu, HY, Morel PA. In vivo imaging platform for tracking immunotherapeutic cells. Nat Biotech 23:983-987. 2005.
Complete Publication Listing
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Other
Links |
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University of Pittsburgh |
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Office:
E1048 BST |
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Lab:
E1014 BST |
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Phone:
412.624.0343 |
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Fax:412.383.7224 |
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morel@pitt.edu |
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Academic
Affiliations |
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- Professor, Department of Immunology, University of Pittsburgh School of Medicine
- Professor, Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine
- Member, University of Pittsburgh Arthritis Institute
- Member, University of Pittsburgh Cancer Institute
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Education |
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- B.M. - Univ. Southampton Medical School (1979)
- M.D. - Univ. Geneva Fac. Med. (1983)
- Postdoc - Scripps Clin. Res. Fndn. (1983-1985)
- Postdoc - Stanford Univ. (1985-1987)
- Postdoc - Univ. Pittsburgh (1988)
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Grant
Support |
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- Title: 19F MRI Proves and Autoimmune Disease Protection
Agency: NIH
Role: Co-P.I.
Funding Period: 2005-2009
- Title: Modeling Immunity for Biodefense
Agency: NIH/NIAID
Role: Project Director and Project Leader
Funding Period: 2005-2010
- Title: Dendritic cells prevent type 1 diabetes by inducing Treg cells
Agency: ADA
Role: P.I.
Funding Period: 2006-2008
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Lab
Personnel |
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Postdoctoral Associate
Michael Turner, Ph.D.
Research Specialist
Huijie Sun |
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