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Research
Interests |
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Immunology and Pathogenesis of Tuberculosis
Tuberculosis kills ~2 million people per year, worldwide. WE use various animal models to study T cell, macrophage, dendritic cell, cytokine and chemokine responses to Mycobacterium tuberculosis in the lungs. Our goal is to define immune mechanisms that enhance resistance to this infection, as well as those that exacerbate pathology. We have funded projects on CD4T cells, CD8 T cells, granuloma formation, and TNF-a in tuberculosis. We study both the acute and latent phase of infection, since it is estimated that 1/3 of the world's population is latently infected, and 10% of infected persons will develop active disease. These studies may lead to improved vaccine development or immunotherapeutic strategies, as well as a clear understanding of the host-pathogen interactions in tuberculosis.
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Selected
Publications |
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- Board KF, Patil S, Lebedeva I, Capuano S 3rd, Trichel AM, Murphey-Corb M, Rajakumar PA, Flynn JL, Haidaris CG, Norris KA. Experimental Pneumocystis carinii pneumonia in simian immunodeficiency virus-infected rhesus macaques. J Infect Dis 187(4):576-88. 2003.
- Scott HM, Flynn JL. Mycobacterium tuberculosis in chemokine receptor 2-deficient mice: influence of dose on disease progression. Infect Immun 70(11):5946-54. 2002.
- Croix DA, Board K, Capuano S 3rd, Murphey-Corb M, Haidaris CG, Flynn JL, Reinhart T, Norris KA. Alterations in T lymphocyte profiles of bronchoalveolar lavage fluid from SIV- and Pneumocystis carinii-coinfected rhesus macaques. AIDS Res Hum Retroviruses 18(5):391-401. 2002.
- Serbina NV, Lazarevic V, Flynn JL. CD4(+) T cells are required for the development of cytotoxic CD8(+) T cells during Mycobacterium tuberculosis infection. J Immunol 167(12):6991-7000. 2001.
- Scanga CA, Mohan VP, Tanaka K, Alland D, Flynn JL, Chan J. The inducible nitric oxide synthase locus confers protection against aerogenic challenge of both clinical and laboratory strains of Mycobacterium tuberculosis in mice. Infect Immun 69(12):7711-7. 2001.
Complete Publication Listing
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Other
Links |
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MGB Faculty Webpage
CVR Webpage
University of Pittsburgh |
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Office:
W1157 BST |
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Lab:
W1112 BST |
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Phone:
412.624.7743 |
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Fax:412.383.7220 |
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joanne@pitt.edu |
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Academic
Affiliations |
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- Professor, Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine
- Professor, Department of Medicine, Division of Infectious Disease, University of Pittsburgh School of Medicine
- Professor, Department of Immunology, University of Pittsburgh School of Medicine
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Education |
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- B.S. - University of California, Davis (1982)
- Ph.D. - Microbiology and Immunology, University of California, Berkeley (1987)
- Postdoc - Scripps Clinic (1987-1990)
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Grant
Support |
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- Title: Role of CD8 T cells in tuberculosis.
Agency: NIH
Role: P.I.
- Title: A non-human primate model of tuberculosis and AIDS
Agency: NIH
Role: P.I.
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Lab
Personnel |
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Graduate Students
Kendra Bodnar
Holly Scott
Vanja Lazarevic
Post-doctoral Fellows
Denise Croix, Ph.D.
Santosh Pawar, Ph.D.
Infectious Disease Fellows
Dawn Nolt, M.D.
Ling Lin, M.D.
Veterinarian
Saverio Capuano, D.V.M.
Technicians
Amy Myers
Angelica Zinovik |
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