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Research
Interests |
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- Dendritic cell biology in the non-human primate. This project focuses on the behavior of dendritic cells in monkeys, studying both monocyte-derived dendritic cells as well as Langerhans cells and lymph node dendritic cells in situ. Emphases are on antigen uptake by dendritic cells, and the effects of SIV infection on dendritic cell function, including migration and activation.
- Dendritic cell-based vaccines for SIV infection in the monkey. This project utilizes in vitro monocyte-derived dendritic cells as antigen-delivery vehicles for SIV vaccination and immunotherapy in the rhesus macaque. Antigens are introduced via recombinant adenoviruses encoding SIV genes. Other areas of investigation include using virus-infected cells as a source of antigen for dendritic cells.
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Selected
Publications |
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- Michael I. Zimmer, Adriana T. Larrengina, Cielo M. Castillo, Saverio Capuano III, Louis D. Falo Jr., Michael Murphey-Corb, Todd A. Reinhart, and Simon M. Barratt-Boyes. Disrupted homeostasis of Langerhans cells and interdigitating dendritic cells in monkeys with AIDS. Blood. 15 April, 2002, Vol. 99, No. 8, pp. 2859-2868.
- Barratt-Boyes, S.M., Zimmer, M.I., Harshyne, L.A., Meyer, E.M., Watkins, S.C., Capuano, S., Murphey-Corb, M., Falo, L.D. and Donnenberg, A.D. (2000). Maturation and trafficking of monocyte-derived dendritic cells in monkeys: Implications for dendritic cell-based vaccines. J. Immunol. 164:2487-2495.
- Harshyne, L.A., Watkins, S.C., Gambotto, A. and Barratt-Boyes, S.M. (2001). Dendritic cells acquire antigens from live cells for cross-presentation to CTL. J. Immunol. 166:3717-3723.
Complete Publication Listing
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Other
Links |
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CVR Webpage
University of Pittsburgh |
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Office:
723 Parran Hall |
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Lab:
724 Parran Hall |
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Phone:
412.383.7537 |
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Fax:412.383.8926 |
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smbb@pitt.edu |
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Academic
Affiliations |
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- Associate Professor, Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh
- Associate Professor, Department of Immunology, University of Pittsburgh
- Member, University of Pittsburgh Cancer Institute
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Education |
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- B.V.Sc. - Massey University (1984)
- Ph.D. - University at California at Davis (1993)
- Postdoc - University of Pittsburgh School of Medicine (1997)
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Grant
Support |
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- Title: Dendritic cell based therapy for HIV: SIV model
Agency: NIH
Role: P.I.
Funding Period: 1998-2002
- Title: RO1: Whole autologous SIV vaccine using dendritic cells
Role: P.I.
Funding Period: 2002-2007
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Lab
Personnel |
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Graduate Students
Larry Harshyne
Mike Zimmer
Research Specialist
Kevin Brown |
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