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Research
Interests |
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- Tumor-localization by anti-tumor effector cells: The trafficking of non-specific (e.g., NK cells and polyclonally activated T cells) as well as specific T-cells is investigated. Of special interest are the mechanisms the effector cells use to discriminate between malignant and normal tissues. Ways to improve effector cell localization into malignant tissues are explored.
- Anti-tumor effect of specific and non-specific effector cells: The ability of non-specific (especially NK cells) and specific effector cells to localize into and attack the tumors is investigated. Ways to enhance the efficacy of the tumor-infiltrating effector cells are explored. The overall goal is to develop efficient, but non-toxic protocols for cancer immunotherapy.
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Selected
Publications |
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- Hokland, M., Kjaergaard, J., Kuppen, P.J., Nannmark, U., Agger, R., Hokland, P., and Basse, P. Endogenous and adoptively transferred A-NK and T-LAK cells continuously accumulate within murine metastases up to 48 h after innoculation. In Vivo 13: 199-204, 1999.
- Jorgen Kjaergaard, Marianne E. Hokland, Ralf Agger, Anni Skovbo, Ulf Nannmark, and Per H. Basse. Biodistribution and Tumor Localization of T-LAK Cells Following Different Routes of Administration into Tumor Bearing Animals. Cancer Immunology. Immunother. 48: 550-560, 2000.
- Nannmark U, Hokland ME, Agger R, Christiansen M, Kjaergaard J, Goldfarb RH, Bagge U, Unger M, Johansson BR, Albertsson PA & Basse PH. Tumor blood supply and tumor localization by adoptively transferred IL-2 activated natural killer cells. In Vivo 14: 651-658, 2000.
Complete Publication Listing
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Other
Links |
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University of Pittsburgh |
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Academic
Affiliations |
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- Assistant Professor, Department of Pathology, School of Medicine, University of Pittsburgh
- Member, University of Pittsburgh Cancer Institute
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Education |
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- M.D. - University of Aarhus (1984)
- Ph.D. - University of Aarhus (1992)
- D.M.Sci. - University of Aarhus (1996)
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Grant
Support |
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- Title: Therapy with Activated Natural Killer Cells
Agency: NIH
Role: Project leader, Core leader
Funding Period: 1997-2002
- Title: How are breast cancer metastases able to survive and grow in draining lymph nodes?
Agency: Department of Defense
Role: P.I.
Funding Period: 2001-2002
- Title: Treatment of Lung Malignancies with Prodrug-Activating Natural Killer Cells
Agency: ACS
Role: P.I.
Funding Period: 2000-2003
- Title: Adjuvant immunotherapy of small cell lung cancer using adoptive transfer of activated natural killer cells and IL-2.
Agency: NIH
Role : Collaborator
Funding Period: 2001-2004
- Title: A new strategy for targeted chemoimmunotherapy of cancer
Agency: NIH
Role: P.I.
Funding Period: 2002-2005
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Lab
Personnel |
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Research Associate
Qin Yang, M.D.
Research Specialists
Lisa Bailey
Daniele Cary
Patricia Rice
Rotation Students
Steve Goding |
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