MSMVM 2400 MS Thesis Research (1-14 cr). A directed research project leading to a thesis for a Master's degree. All semesters. MSMVM 2410 Molecular Virology (2 cr). This course stresses basic concepts of animal virology. Subjects include different viruses, the expression and regulation of viral genes, the mechanisms of viral-induced cytopathology, latency, and cell transformation, and the nature of viroids and prions. Lecture format. Foundations of Biomedical Sciences, or an equivalent course (approved by Course Director) is a prerequisite. Spring semesters. (DeLuca/Reinhart) MSMVM 2420 Experimental Virology (1 cr). This course is designed to teach students entering graduate research projects involving viruses to critically evaluate the scientific literature in terms of experimental strategies, presentation and interpretation of data, justification of conclusions made in published articles. Paper discussion format. Completion or concurrent registration in Molecular Virology (or equivalent) required. This course is coordinated with, but independent from Molecular Virology lectures. May be taken only one time for credit. Spring semesters. (Kinchington) MSMVM 2430 Microbiology Teaching Assistant (1 cr). The purpose of this course is to introduce graduate students of the Integrated Biomedical Sciences Graduate Program to the principles of teaching. The students will be trained in basic teaching techniques as well as provided material for teaching students specific concepts. As part of this course, students will participate in teaching first-year medical students the fundamentals of microbiology, in conjunction with the Laboratory and Problem Based Learning sections of the Molecular Pathogenesis of Infectious Disease course of Basic Science Medical School block. Each student will be responsible for 8-10 medical students in a laboratory setting. The student will present basic laboratory techniques, explain concepts of microbiology and infectious disease, including diagnostic tests, interpretation of results, and data management. In addition, the student will assist the Faculty Facilitator in the Problem Based Learning Sessions where they will review laboratory findings with the students. Spring semesters. (Carroll) MSMVM 2450 Research Seminar (1 cr). The course is a weekly seminar in which the student presents an annual research progress report. Emphasis is placed on a careful analysis and critical evaluation of experimental strategies, data analysis, and the development of skills needed for scientific presentation. The student is expected to elucidate issues relevant to the topic and to answer questions from other graduate students and faculty. Fall and Spring semesters. (Schmidt) MSMVM 2470 Contemporary Topics in Molecular Virology and Microbiology (1 cr). This research paper discussion course is designed to teach students to critically evaluate and present published data in contemporary scientific research articles. Students, in consultation with the course director, select published articles for presentation and discussion. A topic is chosen for each semester. Fall and Spring semesters. Restricted to MVM graduate students or by special permission of instructor. (Montelaro/Mietzner) MSMVM 2490 Directed Study (1-9 cr) This course provides the student an opportunity to carry out a specific laboratory project in any area of interest in MVM. All semesters. MSMVM 3400 Ph.D. Dissertation Research (1¨C14 cr). After advancement to candidacy for the PhD degree, students enroll in this course to pursue original experimental laboratory research, the results of which will provide the substance of their doctoral dissertation. A minimum of 40 credits of this course are required for the Ph.D. degree in the School of Medicine. All semesters. MSMVM 3410 Microbial Pathogenesis (2 cr). This course is an introduction to molecular basis of bacterial and parasitic pathogenesis. Topics include microbial physiology and genetics, gene expression, virulence factors, pathogenic strategies of bacterial agents. Lecture format. Foundations of Biomedical Sciences, or an equivalent course (approved by Course Director) is a prerequisite. Spring semesters. (Flynn) MSMVM 3415 Experimental Microbial Pathogenesis (1 cr). This course is designed to teach students entering graduate research projects involving microbial pathogenesis to critically evaluate the scientific literature in terms of experimental strategies, presentation and interpretation of data, justification of conclusions made in published articles. Paper discussion format. Completion or concurrent registration in Microbial Pathogenesis (or equivalent) required. This course is coordinated with, but independent from, Microbial Pathogenesis lectures. May be taken only one time for credit. Spring semesters. (Nau) MSMVM 3420 Viral Pathogenesis (2 cr). The goal of this course is to integrate the lectures given on a particular virus in the comprehensive virology course with two additional lectures which expand the basic biology of the virus life cycle to the level of virus-host interactions. The first lecture will address the pathogenic properties of the virus from the perspective of disease manifestations, immunology, and the natural history of infection. This will be followed by a second lecture that will address the molecular basis of viral pathogenesis and current advances in antiviral research. Lecture/paper discussion format. Molecular Virology (or equivalent) required. Fall semesters. (Gupta) MSMVM 3425 Pathogen: Host Interactions (2 cr). This advanced topics course will focus on the interactions between pathogens (viral or uni-cellular microbe) and their hosts that alter cellular metabolism of gene expression, at a mechanistic level. The course will consist of discussions of current papers in the field along with supplemental lectures. Wherever possible, we will consider studies that use functional genomics as a approach to study pathogen-host interactions. Considering the emerging utility of functional genomics in microbiology, lectures will also be devoted to microarray construction, use and analysis. Alternate Fall semesters. (DeLuca) MSMVM 3430 Retrovirology (2 cr). Retroviruses such as HIV-1, the virus which causes AIDS, are currently of extreme medical significance. In this course, the complex molecular biology and biochemistry of retroviruses will be examined. The student completing this course will have an in-depth under-standing of the current retrovirus literature. Lecture/Paper discussion format. Virology, Microbiology and Immunology background required. Alternate Fall semesters. (Cole/Ayyavoo) MSMVM 3440 Vaccines and Immunity (2 cr). The course will cover the current and experimental vaccines for infectious agents, cancer, and other human diseases. The students will be expected to 1) understand the immunity elicited by current vaccines, 2) understand the strategies used to design effective vaccines against various diseases, 3) expand and integrate their understanding of innate and adaptive immune responses in order to improve vaccines, and 4) design new regimens to tackle agents without vaccines and understand the challenges in designing these strategies. Alternate Spring semesters. (Ross) MSMVM 3450 Herpes Virology (2 cr). The focus of this course will be molecular biology and pathogenesis of the 8 known herpes viruses that infect and cause disease in man. It will cover the molecular details for the life cycles of these viruses, including attachment, entry, gene expression, replication, assembly, latency, immunology, and pathogenesis. There will be discussions concerning antiviral approaches, vaccines, and the use of herpes viruses as gene transfer vectors. Lecture/paper discussion format. Alternate Spring semesters. (Jenkins) MSMVM 3455 Antimicrobial therapeutics (2 cr.). The course will provide detailed information at the molecular level describing the development and mechanism of action of antimicrobial drugs. Topics to be discussed include anti-bacterial, anti-fungal, anti-parasitic, and anti-viral (including anti-retroviral) agents. Some emphasis will be placed on diseases with significant public health impact. The course will encompass aspects of medicinal chemistry, biochemistry, and molecular biology. Alternate Fall semesters. (Parniak) MSMVM 3465 Gene Delivery (2 cr). The prospect of using genetically engineered viruses to infect human cells has led to the development of the science of viral vectors. His course will discuss the basic strategies for the development of viral vectors as well as their molecular biology and biochemistry. Lecture/paper discussion format. Alternate Spring semesters. (Faculty) MSMVM 3480 Immunology of Infectious Diseases (2 cr). This course examines the immune responses to pathogens, as well as on immune evasion of microbes. The organisms studied include bacteria, parasites, and viruses. Topics focus on host-pathogen interaction and include innate immunity, modulation of antigen processing and presentation, pathogenic strategies for subversion of immune responses, effector functions of immune cells, and immunopathology. Graduate level immunology is a prerequisite. Lecture/paper discussion format. Alternate Fall semesters. (Flynn/Norris) MSMVM 3470 Advanced Topics in Molecular Virology and Microbiology (2 cr). This course is offered to address topics of special interest, as needed. Lecture/research paper discussion format. Students or faculty may suggest advanced topics courses. Offered as needed. MSMVM 3496 Molecular Virology Conference (1 cr). This in-depth course deals with new topics of molecular virology. Spring Semester.