Research Interests Dendritic cell biology in the non-human primate. This project focuses on the behavior of dendritic cells in monkeys, studying both monocyte-derived dendritic cells as well as Langerhans cells and lymph node dendritic cells in situ. Emphases are on antigen uptake by dendritic cells, and the effects of SIV infection on dendritic cell function, including migration and activation. Dendritic cell-based vaccines for SIV infection in the monkey. This project utilizes in vitro monocyte-derived dendritic cells as antigen-delivery vehicles for SIV vaccination and immunotherapy in the rhesus macaque. Antigens are introduced via recombinant adenoviruses encoding SIV genes. Other areas of investigation include using virus-infected cells as a source of antigen for dendritic cells.   Selected Publications Gambotto A, Barratt-Boyes SM, de Jong MD, Neumann G, Kawaoka Y. Human infection with highly pathogenic H5N1 influenza virus. Lancet. 2008 Apr 26;371(9622):1464-75. Review. Qin S, Sui Y, Soloff AC, Junecko BA, Kirschner DE, Murphey-Corb MA, Watkins SC, Tarwater PM, Pease JE, Barratt-Boyes SM, Reinhart TA.Chemokine and cytokine mediated loss of regulatory T cells in lymph nodes during pathogenic simian immuno-deficiency virus infection. J Immunol. 2008 Apr 15;180(8):5530-6. Melhem NM, Liu XD, Boczkowski D, Gilboa E, Barratt-Boyes SM. Robust CD4(+) and CD8(+) T cell responses to SIV using mRNA-transfected DC expressing autologous viral Ag. Eur J Immunol. 2007 Aug;37(8):2164-73. Brown KN, Trichel A, Barratt-Boyes SM. Parallel loss of myeloid and plasmacytoid dendritic cells from blood and lymphoid tissue in simian AIDS. J Immunol. 2007 Jun 1;178(11):6958-67. Morelli AE, Coates PT, Shufesky WJ, Barratt-Boyes SM, Fung JJ, Demetris AJ, Thomson AW. Growth factor-induced mobilization of dendritic cells in kidney and liver of rhesus macaques: implications for trans-plantation. Transplantation. 2007 Mar 15;83(5):656-62. Complete Publication Listing   Grant Support NIH/ NIAID: Dendritic cell dynamics in peripheral and lymphoid tissues in SIV infection. Principal Investigator NIH/NCI: Dendritic cell biology and therapy. Co-Investigator   Other Links IDM Webpage CVR Webpage University of Pittsburgh

Simon M. Barratt-Boyes, Ph.D. Office:  9046 BST3, Cntr. for Vaccine Research Lab:9053 BST3, Center for Vaccine Research Phone:412-383-7537 smbb@pitt.edu   Academic Affiliations Assistant Professor Department of Infectious Diseases and Microbiology Graduate School of Public Health Member, University of Pittsburgh Cancer Institute   Education 1984 - B.V.Sc. Massey University, New Zealand 1993 - Ph.D. University of California at Davis 1997 - Postdoc University of Pittsburgh School of Medicine   Lab Personnel Graduate Students: Larry Harshyne Mike Zimmer Research Specialist: Kevin Brown Lab phone: 412-383-9057