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Research InterestsOur laboratory, the Pittsburgh Retrovirus Laboratory, plays a central role in many virological studies related to human immunodeficiency virus (HIV) at the University of Pittsburgh. Studies are being conducted to elucidate the mechanism of HIV induced pathogenesis at the cellular and molecular level. This study has demonstrated the presence of HIV with distinct biologic and genetic properties that are associated with different stages of HIV disease.
We have recently shown that enhanced expression of HIV RNA is associated with the development of AIDS. Consequently, HIV-infected subjects who remain asymptomatic for a long period of time harbor low levels of HIV-1 RNA. Recent studies have indicated that lower expression of viral RNA could be due to a defect in translocation of proviral DNA into nucleus which results in loss of integration of proviral DNA into host chromosome. Studies are also being done to investigate the mechanism of cell-to-cell transmission of HIV and to examine the interaction of HIV and herpes viruses which may act as cofactors in the development of AIDS.
The Retrovirus Laboratory is also involved in multicenter epidemiological studies on the natural history of AIDS which examine genetic varition of HIV and the latency period of HIV infection in infected subjects.
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Selected Publications- Gupta P, Chen Y. Chromosomal engineering of Clostridium perfringens using group II introns. Methods Mol Biol. 2008;435:217-28.
- Shen C, Gupta P, Wu H, Chen X, Huang X, Zhou Y, Chen Y. Molecular characterization of the HIV type 1 vpr gene in infected Chinese former blood/plasma donors at different stages of diseases. AIDS Res Hum Retroviruses. 2008 Apr;24(4):661-6.
- Sayeed S, Uzal FA, Fisher DJ, Saputo J, Vidal JE, Chen Y, Gupta P, Rood JI, McClane BA. Beta toxin is essential for the intestinal virulence of Clostridium perfringens type C disease isolate CN3685 in a rabbit ileal loop model. Mol Microbiol. 2008 Jan;67(1):15-30.
- Rodriguez MA, Shen C, Ratner D, Paranjape RS, Kulkarni SS, Chatterjee R, Gupta P. Genetic and functional characterization of the LTR of HIV-1 subtypes A and C circulating in India. AIDS Res Hum Retroviruses. 2007 Nov;23(11):1428-33.
- Sassi AB, Isaacs CE, Moncla BJ, Gupta P, Hillier SL, Rohan LC. Effects of physiological fluids on physical-chemical characteristics and activity of topical vaginal microbicide products.J Pharm Sci. 2007 Oct 5.
Complete Publication Listing
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Grant Support- NIH/NIAID: CV-N-secreting Lactobacilli and Retrocyclin microbicides.
Principal Investigator - NIH/NIAID: Pitt AIDS Research Training Program.
Principal Investigator - NIH/NIAID: Semen in transmission of HIV.
Principal Investigator - NIH: Fogarty International Training Grant in India and Brazil.
Co-Director - NIH/NIAID: Chemokins modulation during SIV infection & AIDS.
Co-Investigator
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Other
Links
Infectious Diseases and Immunology
University of Pittsburgh |
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Phalguni Gupta, Professor
| Office:
426 Parran Hall/GSPH |
| Lab:430 Parran Hall/GSPH |
| Phone:412-624-7998 |
| Fax: 412-624-4953
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pgupta1@pitt.edu
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Academic Affiliations- Professor, Department of Infectious Diseases and Microbiology/GSPH
- Pathology/SOM
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Education- 1964 - B.S. Chemistry
University of Calcutta, India
- 1966 - M.S. Biochemistry
University of Calculla, India
- 1969 - M.S. Biochemistry
University of Wisconsin
Madison, Wisconsin
- 1972 - Ph.D. Biochemistry
University of Wisconsin
Madison, Wisconsin
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Lab Personnel
Research Assistant Professor:
Yue Chen
Lab Supervisor:
Kathy Kulka
Lab Techs:
Lori Caruso, Ming Ding, Deena Ratner, Mary White
Students:
Ruth Helmus, Poonam Poonam, Jackeline Soto
Post-doc Fellow:
Ashwin Tumne
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