Research Interests The natural history of herpes simplex virus involves repeated cycles of recurrent infection initiated by endogenous latent virus residing in the peripheral nervous system. The overall aims of Dr. Glorioso's research are 1) to understand the genetic basis of latency and neurovirulence, 2) precisely define viral envelope glycoprotein-receptor interactions that occur during virus attachment and entry and devise strategies for retargeting virus infection through recognition of novel receptors, and 3) to develop HSV as a gene transfer vector suitable for treatment of nervous system diseases such as cancer (e.g. glioblasoma), neurodegenerative conditions (e.g. diabetic neuropathy), auto-immune brain disease (e.g. multiple sclerosis) and a variety of types of pain.   Selected Publications Hao S, Wolfe D, Glorioso JC, Mata M, Fink DJ. Effects of transgene-mediated endomorphin-2 in inflam-matory pain. Eur J Pain. 2008 Jun 20. [Epub ahead of print] Li H, Baskaran R, Krisky DM, Bein K, Grandi P, Cohen JB, Glorioso JC. Chk2 is required for HSV-1 ICP0-mediated G2/M arrest and enhancement of virus growth. Virology. 2008 Mar 3. McTiernan CF, Mathier MA, Zhu X, Xiao X, Klein E, Swan CH, Mehdi H, Gibson G, Trichel AM, Glorioso JC, Feldman AM, McCurry KR, London B. Myocarditis following adeno-associated viral gene expression of human soluble TNF receptor (TNFRII-Fc) in baboon hearts. Gene Ther. 2007 Dec;14(23):1613-22. Srinivasan R, Huang S, Chaudhry S, Sculptoreanu A, Krisky D, Cascio M, Friedman PA, de Groat WC, Wolfe D, Glorioso JC. An HSV vector system for selection of ligand-gated ion channel modulators. Nat Methods. 2007 Sep;4(9):733-9. Niranjan A, Fellows W, Stauffer W, Burton EA, Hong CS, Lunsford LD, Kondziolka D, Glorioso JC, Gobbel GT. Survival of transplanted neural progenitor cells enhanced by brain irradiation. J Neurosurg. 2007 Aug;107(2):383-91. Complete Publication Listing   Grant Support NIH/NIAMS: Gene and cell therapy of Duchenne Muscular Dystrophy. Principal Investigator NIH/NCI: Glioma gene therapy using targeted oncolytic HSV vectors. Principal Investigator NIH/NIDDK: Model systems for development of pain gene therapy Principal Investigator NIH/NCI: Clinical grade production of MGH2 HSV-1 viral vector. Co-Investigator ACGT: Alliance for cancer gene therapy Co-Investigator   Other Links MMG Faculty Webpage CVR Webpage University of Pittsburgh

Joseph C. Glorioso, III, Ph.D. Office:  E1246 Biomedical Science Tower Lab:E1202, E1215, E1216 BST and Molecular Medicine Institute labs Phone:412-648-8105 Fax: 412-624-8997 glorioso@pitt.edu   Academic Affiliations William S. McEllroy Professor of Biochemistry Professor and Chairman, Microbiology and Molecular Genetics Director, Molecular Medicine Institute Member, Biochemistry and Molecular Genetics Graduate Program   Education Undergraduate: 1963-1968 University of Southwestern Louisiana B.S. Psychology Lafayette, Louisiana Graduate: 1969-1971 University of Southwestern Louisiana M.S. Microbiology Lafayette, Louisiana Post-Graduate: 1974-1976 Louisiana State University Medical Center Post-doctoral Fellow Department of Microbiology New Orleans, Louisiana   Lab Personnel Assistant Professors: Paulo Grandi, Ph.D., David Krisky, Ph.D. Research Assistant Professors: James B. Wechuck, Ph.D., Darren P. Wolfe, Ph.D. Research Instructor: Justus B. Cohen, Ph.D. Research Associates: Arthur Frampton, Ph.D., Shaohua Huang, Ph.D., Han Li, Ph.D., Ali Ozuer, Ph.D., Hiroaki Uchida, Ph.D. Graduate Students: Rahul Srinivasan, April Sunyog Research Technicians: David Clawson, Adriana Forero, Ying Jiang, Anna Jones, David Klinkenberg