Research Interests My laboratory is interested in human papillomavirus (HPV)-associated carcinogenesis. Specifically, we study how HPV-encoded oncoproteins disrupt mitotic fidelity of infected host cells. Another line of research focuses on DNA damage and replicational stress in HPV-transformed cells.   Selected Publications Duensing A, Duensing S. Centrosome-mediated chromosomal instability and steroid hormones as co factors in human papillomavirus-associated cervical carcinogenesis: small viruses help to answer big questions.Adv Exp Med Biol. 2008;617:109-17. No abstract available. Duensing A, Chin A, Wang L, Kuan SF, Duensing S. Analysis of centrosome overduplication in correlation to cell division errors in high-risk human papillomavirus (HPV)-associated anal neoplasms. Virology. 2008 Mar 1;372(1):157-64. Epub 2007 Nov 26. Spardy N, Duensing A, Charles D, Haines N, Nakahara T, Lambert PF, Duensing S. The human papillomavirus type 16 E7 oncoprotein activates the Fanconi anemia (FA) pathway and causes accelerated chromosomal instability in FA cells.J Virol. 2007 Dec;81(23):13265-70. Epub 2007 Sep 26. Liu Y, Tsend M, Perdreau SA, Rossi F, Antonescu C, Besmer P, Fletcher JA, Duensing S, Duensing A. Histone H2AX is a mediator of gastrointestinal stromal tumor (GIST) cell apoptosis following treatment with imatinib mesylate. Cancer Res.2007.; 67:2685-2692. Duensing A, Liu Y, Spardy N, Bartoli K, Tseng M, Kwon JA, Teng X, Duensing S. RNA polymerase II transcription is required for human papillomavirus type 16 E7- and hydroxyurea-induced centriole overduplication. Oncogene. 2007 Jan 11;26(2):215-23. Complete Publication Listing   Grant Support "Genomic instbility induced by the HPV-16 E7 oncoprotein." NIH/NCR R01 07/01/05-04/30/10 Principal Investigator "Prevention of chromosomal instability in breast cancer by indigo-derived CDK inhibitors." Susan G. Komen Breast Cancer Foundation 05/01/06-04/30/09 Principal Investigator "Causes and consequences of genomic instability induced by HPV oncoproteins." American Cancer Society Research Scholar Grant 01/01/07-12/31/10 Principal Investigator "Identification of novel biomarkers for PHV-associated anal cancer." The Pittsburgh Foundation GLBT Health and Wellness Fund 11/15/06-11/14/07 Principal Investigator   Other Links University of Pittsburgh

Stefan Duensing, M.D. Office:  Hillman Cancer Center Research Pavilion Suite 1.8 Lab: Hillman Research Pavillion Suite 1.7 Phone: 412-623-7719 Fax: 412-623-7715 duensing+@pitt.edu   Academic Affiliations Assistant Professor Dept. of Microbiology and Molecular Genetics University of Pittsburgh Molecular Virology Program University of Pittsburgh Cancer Institute Member, Biochemistry and Molecular Genetics Graduate Program   Education 1990-1994 M.D. Hannover Medical School, Germany 1994-2997 Ph.D. Medical Oncology Hannover Medical School, Germany 1997-1998 Fellow Pathology Hannover Medical School, Germany 1999-2003 Postdoctoral Fellow Molecular Virology Harvard Medical School, Boston, MA   Lab Personnel Research Assistant Professor: Anette Buensing, MD Postdoctoral Fellow: Rajesh Soni, PhD Graduate Student: Nicole Spardy Research Assistant: Payel Chatterjee Volunteers: Elliott Cha and Anna Chin