Our lab is interested in understanding what drives age-related diseases and aging. The goal is to define interventions that can improve health and quality of life. Our lab uses C. elegans, mice, induced pluripotent stem cells (iPSc) and patient samples to understand the basic biology of aging. Potential projects include:
1. Role of lipid metabolism and epigenetics in aging.
2. Understanding the role of DNA damage-induced cellular senescence in cardiovascular disease.
3. Integration -omic and causal inference to translate ‘aging’ from bedside to bench.
Techniques commonly used in the lab vary from cell culture, molecular biology, immunofluorescence, single cell RNA-seq and data integration (metabolomics, lipidomics, RNA-seq), phenotyping mice including frailty and skeletal muscle integrity.