Accepting student for Fall 2026.
The McCloskey lab focuses on understanding how cellular and tissue-level heterogeneity shapes the development and progression of breast and ovarian cancers. Our group employs functional and computational approaches that integrate multi-omics and advanced imaging technologies to dissect the biology of cancer risk, including how hereditary BRCA1 variants and modulable lifestyle factors shape epithelial progenitors in tissues-of-origin. By combining these experimental and computational strategies, the lab aims to define key molecular and cellular vulnerabilities across diverse tissue and tumor microenvironments. Ultimately, our work seeks to advance precision prevention and precision treatment strategies, with direct impact on improving outcomes for patients with hereditary and sporadic cancers.