Understanding the role of platelet mitochondrial signaling in pulmonary hypertension and aging.
Dr. Shiva’s research focuses broadly on understanding the mechanisms by which mitochondrial function is regulated, particularly by reactive oxygen and nitrogen species and the contribution of these mechanisms to cardiovascular health and disease pathogenesis. Using a wide spectrum of techniques ranging from the biochemical study of isolated mitochondria to whole animal models and measurement of bioenergetic function in human blood cells, the Shiva lab is currently engaged in a number of active projects along four major scientific themes:
1 – Utilization of platelets to measure human mitochondrial function in health and disease
2 – The role of platelet mitochondria in hemolytic disease pathogenesis
3 – The mitochondrion as a physiological target for nitrite
4 – Myoglobin as a regulator of mitochondrial function