Accepting New Students
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Project Accepting Students
| We determined osteopenia in the inborn error of metabolism PAH deficient phenylketonuria owes to mesenchymal stem cell developmental defect precipitated by oxidative stress and mitochondrial energy deficit. In the Pahenu2 classical PKU mouse model, we are applying oximetry, respirometry, oxidative stress assessment, and molecular means to characterize pathophysiological mechanisms and design interventions. |
Program 1
Program 1 Research Interests
Intoxicating type inborn errors of metabolism: genetics, genomic assessment to identify genetic modifiers of the primary phenotype(s), and the role of epigenetic modification in disease presentation
Program 1 Faculty Information