• Over nutrition, abnormal mitochondrial function and the pathogenesis of insulin resistance and MASLD.
• Mitochondrial quality control by the PARKIN-mediated mitophagy pathway.
• Mitochondrial protein import regulation by the deubiquitinase USP30 and mitochondrial to nuclear retrograde signaling and cellular remodeling.
• Zonal differences in hepatic metabolism and mitochondrial quality control during MASLD.
• Metabolomics and use of isotopes to measure metabolic turnover and flux in vivo.
• Gfral-independent effects of hepatocyte-derived GDF15. Implications for cancer immunotherapy and obesity/type 2 diabetes.
• Senescence-induced changes in metabolism and mitochondrial function.
• Cystic Fibrosis related diabetes, glucotoxicity and insulin resistance.
Accepting New Students
Yes
Project Accepting Students
Program 1
Program 1 Research Interests
Rrelationship between nutrient excess, mitochondrial overload and the pathogenesis of metabolic diseases, such as fatty liver, insulin resistance and type 2 diabetes
Program 1 Faculty Information