Current projects include:
• Mechanisms of receptor evoked cytosolic Ca2+ oscillations in non-excitable cells and the role of native STIM, Orai and IP3 receptors in shaping the cytosolic Ca2+ microdomains that control the activation of nuclear factor for activated T cells (NFAT) transcription factors isoforms.
• The role of the mitochondrial Ca2+ uniporter (MCU) and the Na+/Ca2+ exchanger (NCLX) in transcriptional programs that control cell growth, metabolism, and invasion of colorectal cancer.
• Control of transcriptional and metabolic reprogramming of smooth muscle remodeling in hypertension and asthma by Ca2+ signals through CRAC channels.
• Regulation of brown adipose tissue function, thermogenesis, and obesity by Orai3-mediated Ca2+ signaling.
• Molecular make-up of CRAC channels in B lymphocytes and contribution of Orai isoforms to B cell activation, antibody production and humoral immunity.
• Interorganellar Ca2+ transfer between cytosol-mitochondria-endoplasmic reticulum and role in cellular bioenergetics, mitochondrial dynamics, and transcriptional regulation.
Accepting New Students
Yes
Project Accepting Students
Program 1
Program 1 Research Interests
Cancer Pharmacology; Cardiovascular and Renal Pharmacology; Pharmacology of Cell and Organ Systems; Receptor Pharmacology; Signal Transduction
Program 1 Faculty Information